What Sleep Duration Matters Most to Brain Health?

Disrupted sleep is common in late life, the study authors wrote, and associated with changes in cognitive function - the mental capacity for learning, thinking, reasoning, problem-solving, decision-making, remembering and paying attention.

Age-related changes in sleep have also been linked with early signs of Alzheimer's disease, depression and cardiovascular disease, so the authors investigated possible associations between self-reported sleep duration, demographic and lifestyle factors, subjective and objective cognitive function, and participants' levels of beta amyloid. 

The older adults with inadequate sleep also performed moderately to significantly worse on tests commonly used on older adults for assessing cognitive abilities, including orientation, attention, memory, language and visual-spatial skills; and identifying mild dementia.

Sleeping too much was also associated with lesser executive function, but those people did not have elevated beta amyloid levels. Participants who reported long sleep duration (nine or more hours) scored slightly worse on the Digit Symbol Substitution Test than those who reported normal sleep duration.

The main takeaway is that it is important to maintain healthy sleep late in life. Additionally, both people who get too little sleep and people who get too much sleep had higher body-mass index (BMI) and more depressive symptoms.

Beta Amyloid 101

Beta amyloid or amyloid-β is "a protein created during normal brain cell activity, although we still aren't sure of its function.
Amyloid-β is one of the first detectable markers in the progression of Alzheimer's disease. In Alzheimer's disease, amyloid-β proteins start to build up throughout the brain, sticking together in plaques. Amyloid plaques are more likely to appear as we age, and many people with amyloid built up in their brains remain healthy. About 30% of healthy 70-year-olds will have substantial amounts of amyloid plaques in their brain.

When someone has Alzheimer's disease, the person's brain cells that retrieve, process and store information...degenerate and die. The "amyloid hypothesis," one of the leading theories on the culprit of this destruction, suggests accumulation of the protein might disrupt communication between brain cells, eventually killing them.

Previous research has suggested "that sleep may both help to limit the production of amyloid in the brain and support the drainage system that clears it.
Amyloid-β can start building up many years before obvious Alzheimer's symptoms show. This makes it difficult to tease apart cause and effect when studying sleep problems and Alzheimer's risk, especially if you only look at data from one point in time.

Sleep, Depression and Sociodemographics

The current study analyzed 4,417 participants with an average age of 71.3 years old, from the United States, Canada, Australia and Japan.

Both the short and long-sleep duration groups reported more depressive symptoms than the normal sleep group. There were differences among genders, races and ethnicities, too: being female and having had more years of education were both significantly linked with sleeping longer every night. And when compared with White participants who reported a mean sleep duration of seven hours and nine minutes, Black or African American participants reported a mean sleep duration of 37.9 minutes less. Asian participants reported 27.3 minutes less than White participants, and Latino or Hispanic White participants reported 15 minutes less.

These findings suggest that sleep disparities could be associated with disparities in other aspects of life, such as cardiovascular and metabolic health, socioeconomic factors and "racial discrimination and perceived racism" correlated with less sleep in prior studies, the authors wrote.

This new research is from a large, international study on cognitively healthy people, but it did rely on participants to report their sleep duration rather than measuring it directly," she added. The researchers couldn't assess quality of sleep or time spent in different stages of a sleep cycle, each of which may be an important factor in the link between sleep and cognitive health.

Older adults concerned about these findings should consider sleep as important as diet and exercise for their health. The best evidence suggests that between seven and nine hours of sleep is optimal for most adults and anyone who thinks that their sleep patterns may be affecting their long-term health should speak to their doctor.